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Activin RIB/ALK-4 Products
Receptors for the TGF-beta superfamily comprise two groups, the type I and the type II serine/threonine kinases. These kinases are type I transmembrane proteins, and the two subgroups are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Either a type I or type II receptor may initially bind ligand, followed by recruitment of its alternate-type receptor counterpart to generate a heteromeric signaling complex. Type I receptors are referred to as the Activin Receptor-like Kinases (ALKs), while the type II receptors are named for the ligands they bind.
23 results for "Activin RIB/ALK-4" in Products
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Activin RIB/ALK-4 Products
Receptors for the TGF-beta superfamily comprise two groups, the type I and the type II serine/threonine kinases. These kinases are type I transmembrane proteins, and the two subgroups are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Either a type I or type II receptor may initially bind ligand, followed by recruitment of its alternate-type receptor counterpart to generate a heteromeric signaling complex. Type I receptors are referred to as the Activin Receptor-like Kinases (ALKs), while the type II receptors are named for the ligands they bind.
23 results for "Activin RIB/ALK-4" in Products
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name : | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity : | ≥99% (HPLC) |
SB 431542 synthesized to cGMP guidelines
| Chemical Name : | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity : | ≥99% |
| Source : | NS0 |
| Accession # : | AAA60556 |
| Applications : | Binding Activity |
| Source : | NS0 |
| Accession # : | NP_031421 |
| Applications : | Binding Activity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | Flow Cytometry |
Selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name : | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Purity : | ≥98% (HPLC) |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Knockout Validated, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #126822 |
| Applications : | Block/Neutralize, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #544310 |
| Applications : | CyTOF-ready, Flow Cytometry |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #207304 |
| Applications : | Western Blot |
ALK4 and ALK5 (TGFβRI) inhibitor
| Alternate Names : | LY 2157299 |
| Chemical Name : | 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide |
| Purity : | ≥98% (HPLC) |
Selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name : | 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine |
| Purity : | ≥98% (HPLC) |
Potent TGF-βRI inhibitor
| Chemical Name : | 4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide |
| Purity : | ≥98% (HPLC) |
