5-Lipoxygenase: Proteins and Enzymes

5-Lipoxygenase (5-LO) is a nonheme iron dioxygenase that converts nuclear membrane arachidonic acid into leukotriene A4 (LTA4). 5-LO is found in leukocytes and generally exists in the cytoplasm but may translocate into the nucleus when activated. In the nucleus, its enzyme products impact gene expression; in the cytosol, its products are secreted and contribute to inflammation.