5 results for "5-HT2B Receptor Antagonists Small Molecules and Peptides" in Products
5-HT2B Receptor Antagonists: Small Molecules and Peptides
Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. The functions of 5-HT2B receptors include regulation of differentiation and proliferation of the embryonic and adult heart, gastrointestinal contraction and endothelium-dependent relaxation. Furthermore, 5-HT2B receptor knockout mice exhibit gross heart defects and 5-HT2B overexpression leads to ventricular hypertrophy. The human 5-HT2B receptor gene has been localized to chromosome 2 (2q36.3-q37.1).
High affinity 5-HT2B antagonist; orally active
| Chemical Name: | 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective 5-HT2B and 5-HT2C antagonist; orally active
| Chemical Name: | 3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent, selective 5-HT2B antagonist
| Chemical Name: | N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea |
| Purity: | ≥98% (HPLC) |
High affinity and selective 5-HT2B antagonist
| Alternate Names: | MT 500 |
| Chemical Name: | 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective 5-HT2B antagonist
| Chemical Name: | 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride |
| Purity: | ≥98% (HPLC) |
