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5-HT1B Receptor Antagonists: Small Molecules and Peptides
5-HT1B is a 7TM receptor for serotonin and is expressed on striatal neurons and Purkinje cells in the cerebellum. 5-HT1B ligation inhibits glycinergic signaling, appetite, circadian rhythym light responsiveness, and trigeminal-mediated nociception. It is an important pharmacologic target in the treatment of migrane headaches.
7 results for "5-HT1B Receptor Antagonists Small Molecules and Peptides" in Products
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5-HT1B Receptor Antagonists: Small Molecules and Peptides
5-HT1B is a 7TM receptor for serotonin and is expressed on striatal neurons and Purkinje cells in the cerebellum. 5-HT1B ligation inhibits glycinergic signaling, appetite, circadian rhythym light responsiveness, and trigeminal-mediated nociception. It is an important pharmacologic target in the treatment of migrane headaches.
7 results for "5-HT1B Receptor Antagonists Small Molecules and Peptides" in Products
β3 partial agonist; also 5-HT1A and 5-HT1B antagonist; more active enantiomer of pindolol (Cat. No. 0994)
| Chemical Name : | (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol |
| Purity : | ≥99% (HPLC) |
Selective h5-HT1B antagonist
| Chemical Name : | N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride |
| Purity : | ≥98% (HPLC) |
Selective 5-HT1B antagonist
| Chemical Name : | 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride |
| Purity : | ≥95% (HPLC) |
Selective r5-HT1B antagonist; active in vivo
| Chemical Name : | (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate |
| Purity : | ≥97% (HPLC) |
Potent and selective 5-HT1B and 5-HT1D antagonist
| Chemical Name : | N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride |
| Purity : | ≥99% (HPLC) |
5-HT1B antagonist
| Chemical Name : | 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
5-HT1A and 5-HT1B antagonist; also β-adrenergic antagonist
| Chemical Name : | 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate |
| Purity : | ≥98% (HPLC) |
