Skip to main content

11 beta-HSD1 Products

Type I 11-beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1, HSD11B1 or HSD1) is a microsomal glycoprotein enzyme, with an apparent mass of 36 kDa. HSD-1 catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. 11beta-HSD1 can also catalyze the reverse reaction, the conversion of cortisone to cortisol. 11beta-HSD1 has been detected in a wide range of rat and human tissues, including lung and testis, but highest amounts are expressed in the liver.

Human 11beta-HSD1 shares 79 and 77% sequence identity with mouse and rat 11beta-HSD1, respectively. There are at least 2 isoforms of 11beta-HSD. The other isoform, type II, is expressed predominantly in the kidney and placenta and catalyzes only the 11-beta-dehydrogenation reaction. High levels of cortisol can lead to visceral obesity and particular defects in the expression or function of 11beta-HSD1 have also been associated with insulin resistance and cognitive function.

Show More

17 results for "11 beta-HSD1" in Products

11 beta-HSD1 Products

Type I 11-beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1, HSD11B1 or HSD1) is a microsomal glycoprotein enzyme, with an apparent mass of 36 kDa. HSD-1 catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. 11beta-HSD1 can also catalyze the reverse reaction, the conversion of cortisone to cortisol. 11beta-HSD1 has been detected in a wide range of rat and human tissues, including lung and testis, but highest amounts are expressed in the liver.

Human 11beta-HSD1 shares 79 and 77% sequence identity with mouse and rat 11beta-HSD1, respectively. There are at least 2 isoforms of 11beta-HSD. The other isoform, type II, is expressed predominantly in the kidney and placenta and catalyzes only the 11-beta-dehydrogenation reaction. High levels of cortisol can lead to visceral obesity and particular defects in the expression or function of 11beta-HSD1 have also been associated with insulin resistance and cognitive function.

Show More

17 results for "11 beta-HSD1" in Products

IHC, WB, ICC/IF
IHC, WB
IHC, WB
WB, ELISA, KO
IHC, WB

Recombinant Monoclonal Antibody

WB, ELISA, MA, AP
Catalog #: H00003290-D01P
WB
Catalog #: NBP2-48879PEP
AC
Catalog #: NB300-934PEP
AC

11-β hydroxylase inhibitor

Potent and selective 11β-hydroxysteroid dehydrogenase inhibitor

Proapoptotic; downregulates Bcl-2 and Bcl-XL

Results Per Page
5 10 25 50
/ 1