Innovative and High Performance Neuroscience Reagents
The functioning of the nervous systems is dependent upon the coordinated actions of a vast array of receptors, neurotransmitters, transporters, ion channels and other signaling proteins. Thus, in order to understand the role of specific targets in neurological systems and/or disease states, neuroscientists need a toolbox of small molecules that allow them to investigate, modulate and control neural cell functioning. Bio-Techne offers a unique catalog of Tocris® high performance life science reagents for neuroscience research, backed up by 30-years of industry-leading experience. The Tocris catalog includes neurotransmitter receptor agonists and antagonists, ion channel blockers, enzyme inhibitors, fluorescent dyes and probes, and caged compounds.
Modulate and Control Neuronal Communication
Neurotransmission, or synaptic transmission, involves the passage of signals from one neuron to another. Synaptic communication, and the action potentials on which it is dependent, are integral for all informational processing capabilities of the brain. Bio-Techne offers a unique collection of Tocris small molecules for neurotransmission research, including research standards and exciting new chemical tools.
- Neurotransmitter receptor agonists and antagonists
- Ion channel modulators
- Neurotransmitter transporters
- Chemogenetic compounds, consisting of DREADD ligands and PSEMs for in vitro and in vivo control of neuronal activity
- Caged compounds and photoswitchable ligands for activity optopharmacological manipulation of neurotransmitter receptor
Investigate Inflammatory and Immune Processes in the Brain
As the host defense mechanism of the central nervous system (CNS), neuroinflammation protects normal brain function and structure in response to injury and infection. Neuroinflammatory processes may be beneficial, leading to the clearance of unwanted material and dying cells in healthy brain development, but also pathogenic, causing neuronal cell death and the production of antibodies against CNS proteins. Neuroinflammation is a key pathogenic feature of many neurodegenerative diseases.
Investigate Neuroendocrinology Pathways with Small Molecules and Peptides
Neuropeptides integrate with peptide hormones to regulate diverse physiological processes, including feeding and appetite, cardiovascular function and circadian rhythms. The Tocris® range of reagents includes small molecules and peptides for the investigation of neuroendocrinology pathways.
Neural Stem Cells
Reprogram, Differentiate and Culture with Small Molecules
The clinical application of stem cells in neuroscience, particularly in neurodegenerative diseases, is an expanding area of research. Small molecules offer advantages over traditional reprogramming and differentiation methods, enabling fast production of a large number of cells.