Innovative and High Performance Neuroscience Reagents
The functioning of the nervous systems is dependent upon the coordinated actions of a vast array of receptors, neurotransmitters, transporters, ion channels and other signaling proteins. In order to understand the role of specific targets in neurological systems and/or disease states, neuroscientists require a toolbox of small molecules to investigate, modulate and control neural cell functioning. Bio-Techne, through the Tocris™ brand offers a unique catalog of high performance life science reagents for neuroscience research, backed up by 30-years of industry-leading experience. The Tocris catalog includes neurotransmitter receptor agonists and antagonists, ion channel blockers, enzyme inhibitors, fluorescent dyes and probes, and caged compounds.
Modulate and Control Neuronal Communication
Neurotransmission, or synaptic transmission, involves the passage of signals from one neuron to another. Synaptic communication, and the action potentials on which it is dependent, are integral for all informational processing capabilities of the brain. Bio-Techne offers a unique collection of Tocris small molecules for neurotransmission research, including research standards and exciting new chemical tools.
- Neurotransmitter receptor agonists and antagonists
- Ion channel modulators
- Neurotransmitter transporters
- Chemogenetic compounds, including of DREADD ligands and PSEMs for in vitro and in vivo control of neuronal activity
- Caged compounds and photoswitchable ligands for activity optopharmacological manipulation of neurotransmitter receptor
Resources for Neurotransmission Research
Antibodies for GPCR Research
Antibodies for GPCR Research
Bio-Techne, through the R&D Systems™ brand, is a leader in the development of GPCR antibodies. We offer the largest selection of highly validated GPCR antibodies in the industry.
Investigate Inflammatory and Immune Processes in the Brain
As the host defense mechanism of the central nervous system (CNS), neuroinflammation protects normal brain function and structure in response to injury and infection. Neuroinflammatory processes may be beneficial, leading to the clearance of unwanted material and dying cells in healthy brain development, but also pathogenic, causing neuronal cell death and the production of antibodies against CNS proteins. Neuroinflammation is a key pathogenic feature of many neurodegenerative diseases.
Neural Stem Cells
Reprogram, Differentiate and Culture with Small Molecules
Neurons generated from stem cells are valuable tools in neuroscience research and can be used to explore neuronal communication. In particular neurons differentiated from patient-derived cells are of interest for investigating disease states. The clinical application of stem cells in neuroscience, especially in neurodegenerative diseases, is also an expanding area of research. Small molecules offer advantages over traditional reprogramming and differentiation methods, enabling fast production of a large number of cells.
Learn more about using small molecules in stem cell workflows
Investigate Neuroendocrinology Pathways with Small Molecules and Peptides
Neuropeptides function alongside neurotransmitters to modulate neuronal transmission. Neuropeptides regulate diverse physiological processes, including feeding and appetite, cardiovascular function, circadian rhythms, and pain as well as behaviors such as anxiety. The Tocris range of reagents includes small molecules and peptides for the investigation of neuroendocrinology pathways.
Neurological Disease Research Areas
Small Molecules for Neurological and Neurodegenerative Disease Research
Resources for Neural Communication Research
Brochure: Huntington's Disease Research Product Guide
Learn about our range of small molecules for Huntington's disease research in this product guide including products for the study of somatic instability, proteolysis and inclusion bodies, transcription dysregulation, and mitochondrial dysfunction among others areas.
Brochure: Immunoassay Solutions for Neuroinflammation
Download this brochure to see how Bio-Techne's Immunoassays are used by your peers to profile cytokine responses to neuroinflammation. Choose the immunoassay that best suits your neuroinflammation research needs.