Huntington's disease (HD) is a neurodegenerative disease characterized by cognitive decline, psychiatric disturbances and motor dysfunction. It is a monogenetic disorder that results in the production of mutant huntingtin (mHTT) mRNA and protein. The aberrant HTT mRNA and protein cause cellular stress that results in synaptic loss and, eventually, apoptosis. Striatal and cortical atrophy is a major hallmark of Huntington's disease, along with mHTT RNA and protein aggregates, which form RNA foci and inclusion bodies in the cell, respectively.
Current Huntington’s disease research is focused on the identification of new therapeutic targets, with a great deal of interest in discovering disease-modifying therapies rather than simply symptomatic treatments. Some of the targets featured are
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Stem Cells
- Regenerative Medicine
- Somatic Instability
Download our brochure to explore the tools available from Bio-Techne to support your Huntington's disease research.