Curcumin
Tocris Bioscience, part of Bio-Techne | Catalog # 2841
Antitumor, anti-inflammatory and antioxidant
Discontinued Product
2841 has been discontinued.
View all Apoptosis Inducer Compounds products.
Key Product Details
Description
Antitumor, anti-inflammatory and antioxidant
Alternative Names
Diferuloylmethane
Product Description
Curcumin is an antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.Product Specifications
Molecular Weight
368.38
Formula
C21H20O6
Storage
Store at -20°C
Chemical Name
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
CAS Number
458-37-7
PubChem ID
969516
InChI Key
VFLDPWHFBUODDF-FCXRPNKRSA-N
SMILES
O=C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)/C=C/C1=CC(OC)=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.68 | 10 | |
| Ethanol | 1.84 | 5 |
Preparing Stock Solutions
for Curcumin
The following data is based on the product molecular weight 368.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.15 mL | 135.73 mL | 271.46 mL |
| 0.5 mM | 5.43 mL | 27.15 mL | 54.29 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.15 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aggarwal and Sung Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 2009 PMID: 19110321
- Miriyala Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569220
- Cole Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569212
- Lin Molecular targets of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569214
- Kuttan Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569210
Product Specific Notices for Curcumin
For research use only
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