Concanamycin A

Name: Concanamycin A
Brand: Tocris Bioscience
SKU: 2656

Tocris Bioscience, part of Bio-Techne | Catalog # 2656

Citations (27)

COA / SDS

H+-ATPase (vacuolar) inhibitor

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

H+-ATPase (vacuolar) inhibitor

Alternative Names

Folimycin

View all H+-ATPase Inhibitors »

Product Description

Concanamycin A is a specific inhibitor of V-type (vacuolar) H⁺-ATPase that displays > 2000-fold selectivity over other H⁺-ATPases (IC₅₀ values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H⁺-ATPases and porcine P-type Na⁺,K⁺-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

Product Specifications

Molecular Weight

866.09

Formula

C₄₆H₇₅NO₁₄

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one

CAS Number

80890-47-7

PubChem ID

6438151

InChI Key

DJZCTUVALDDONK-HQMSUKCRSA-N

SMILES

O=C1O[C@@]([C@@H](C)[C@@H](O)[C@H](C)[C@]2(O)O[C@H](/C=C/C)[C@@H](C)[C@H](O[C@]3([H])O[C@H](C)[C@@H](OC(N)=O)[C@H](O)C3)C2)([H])[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Muroi Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function.
Nishihara Specific inhibitors of vacuolar type H⁺-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm.
Hong Nitric oxide production by the vacuolar-type (H⁺)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 2006 PMID: 16895977