DSPC
Tocris Bioscience, part of Bio-Techne | Catalog # 7943
Neutral phospholipid; component of lipid nanoparticles (LNPs)
Key Product Details
Description
Neutral phospholipid; component of lipid nanoparticles (LNPs)
Alternative Names
1,2-DSPC
Product Description
DSPC is a phosphatidylcholine, a type of neutral phospholipid with two saturated long-chains (18:0). Commonly used in the generation of micelles, liposomes, lipid nanoparticles (LNPs) and other types of artificial membranes. DSPC is used in formulation of LNPs for nonviral drug delivery systems.For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.
For a fully formulate LNP containing DLin-MC3-DMA and a luciferase mRNA reporter, see MC3 LNP Luciferase (Cat. No. 8889).
Product Specifications
Molecular Weight
790.15
Formula
C44H88NO8P
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
1,2-Distearoyl-sn-glycero-3-phosphocholine
CAS Number
816-94-4
PubChem ID
94190
InChI Key
NRJAVPSFFCBXDT-HUESYALOSA-N
SMILES
[C@H](OC(CCCCCCCCCCCCCCCCC)=O)(COP(OCC[N+](C)(C)C)(=O)[O-])COC(CCCCCCCCCCCCCCCCC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| chloroform | 79.01 | 100 | |
| Ethanol | 15.8 | 20 with gentle warming |
Preparing Stock Solutions
for DSPC
The following data is based on the product molecular weight 790.15
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.27 mL | 6.33 mL | 12.66 mL |
| 5 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 10 mM | 0.13 mL | 0.63 mL | 1.27 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Liver-targeted siRNA lipid nanoparticles treat hepatic cirrhosis by dual antifibrotic and anti-inflammatory activities. ACS Nano 2020 PMID: 32378877
- Lou Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J.Control Release 2020 PMID: 32619745
Product Specific Notices for DSPC
For research use only
Loading...
Loading...