2-Hydroxypropyl-β-cyclodextrin
Tocris Bioscience, part of Bio-Techne | Catalog # 0708
Solubilization agent
Key Product Details
Description
Solubilization agent
Alternative Names
HBC,Hydroxypropyl-β-cyclodextrin
Product Description
The most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC.Product Specifications
Molecular Weight
1400.00
Formula
(C6H9O5)7(C3H7O)n
Storage
Store at RT
CAS Number
128446-35-5
PubChem ID
44134771
InChI Key
BZRWCHBEBFPRGF-UHFFFAOYSA-N
SMILES
O[C@@H]1[C@H]8C(COCC(C)O)O[C@H](O[C@H](C(COCC(C)O)O[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O[C@H](C(COCC(C)O)O[C@H](O[C@@H]5C(O)C(O)[C@H](O[C@@H]6C(O)C(O)[C@H](O[C@H](C(COCC(C)O)O[C@H](O8)[C@H]7O)[C@H]7O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)[C@H]4O)[C@@H]4O)OC3COCC(C)O)[C@H]2O)[C@H]2O)[C@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 140 | 100 |
Preparing Stock Solutions
for 2-Hydroxypropyl-β-cyclodextrin
The following data is based on the product molecular weight 1400.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.71 mL | 3.57 mL | 7.14 mL |
| 5 mM | 0.14 mL | 0.71 mL | 1.43 mL |
| 10 mM | 0.07 mL | 0.36 mL | 0.71 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pitha Hydroxypropyl-β-cyclodextrin: preparation and characterisation; effects on solubility of drugs. Int.J.Pharmacol.
- Frijlink The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm.Res. 1991 PMID: 2052529
Product Specific Notices for 2-Hydroxypropyl-β-cyclodextrin
For research use only
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