1,6-Hexanediol

Product Description

1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.Typically used as a 3-10% solution (w/v). Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.

Solubility

Preparing Stock Solutions for 1,6-Hexanediol

The following data is based on the product molecular weight 118.18

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.46 mL	42.31 mL	84.62 mL
5 mM	1.69 mL	8.46 mL	16.92 mL
10 mM	0.85 mL	4.23 mL	8.46 mL
50 mM	0.17 mL	0.85 mL	1.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wheeler Distinct stages in stress granule assembly and disassembly. Elife 2016 PMID: 27602576
• Kroschwald Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters
• Shan Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat.Commun. 2018 PMID: 29467404