2',3'-cGAMP sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 5945
Endogenous high affinity STING agonist
Key Product Details
Description
Endogenous high affinity STING agonist
Product Description
2',3'-cGAMP sodium salt is a endogenous high affinity STING agonist (Kd values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.This product is sold in units of 359μg, equivalent to 0.5μmol.
Product Specifications
Molecular Weight
718.37
Formula
C20H22N10Na2O13P2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
CAS Number
2734858-36-5
PubChem ID
71563406
InChI Key
XRILCFTWUCUKJR-INFSMZHSSA-N
SMILES
[H][C@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@@]([C@H](N6C=NC7=C6N=C(NC7=O)N)O1)([C@@H]2O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.92 | 50 |
Preparing Stock Solutions
for 2',3'-cGAMP sodium salt
The following data is based on the product molecular weight 718.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.78 mL | 13.92 mL | 27.84 mL |
| 2.5 mM | 0.56 mL | 2.78 mL | 5.57 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 25 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Downey DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 2014 PMID: 24940883
- Zhang Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 2015 PMID: 26669264
- Zhang Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 2013 PMID: 23747010
Product Specific Notices for 2',3'-cGAMP sodium salt
For research use only
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