LH 846

Tocris Bioscience, part of Bio-Techne | Catalog # 4896

Selective casein kinase 1δ inhibitor
Discontinued Product
4896 has been discontinued. View all Casein Kinase 1 Inhibitors products.

Key Product Details

Description

Selective casein kinase 1δ inhibitor

View all Casein Kinase 1 Inhibitors »

Product Description

LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.

Product Specifications

Molecular Weight

316.81

Formula

C16H13ClN2OS

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide

CAS Number

639052-78-1

PubChem ID

851474

InChI Key

DYHAMRNAHTWYKY-UHFFFAOYSA-N

SMILES

O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.68 100

Preparing Stock Solutions for LH 846

The following data is based on the product molecular weight 316.81

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.56 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for LH 846

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LH 846

For research use only

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