SGC AAK1 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6528
AAK1 and BMP2K inhibitor; activates Wnt signaling
Key Product Details
Description
AAK1 and BMP2K inhibitor; activates Wnt signaling
Product Description
SGC AAK1 1 is an adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC50 values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.Product Specifications
Molecular Weight
427.52
Formula
C21H25N5O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
CAS Number
2247894-32-0
PubChem ID
134812845
InChI Key
UCBIQZUJJSVQHL-UHFFFAOYSA-N
SMILES
O=C(NC1=NNC2=C1C=CC(C3=CC=CC(NS(=O)(N(CC)CC)=O)=C3)=C2)C4CC4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.75 | 100 |
Preparing Stock Solutions
for SGC AAK1 1
The following data is based on the product molecular weight 427.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.70 mL | 23.39 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Agajanian WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019 PMID: 30605688
Product Specific Notices for SGC AAK1 1
For research use only
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