OXA 06 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5182
Potent ROCK inhibitor
Product Description
OXA 06 dihydrochloride is a potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.Product Specifications
Molecular Weight
404.31
Formula
C21H18FN3.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
CAS Number
1825455-91-1
PubChem ID
91691120
InChI Key
ZRBCUSMZOWMVJS-UHFFFAOYSA-N
SMILES
FC1=CC=CC=C1CNCC(C=C4)=CC=C4C2=C3C(NC=C3)=NC=C2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.43 | 100 |
Preparing Stock Solutions
for OXA 06 dihydrochloride
The following data is based on the product molecular weight 404.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.37 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vigil ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 2012 PMID: 22942252
Product Specific Notices for OXA 06 dihydrochloride
For research use only
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