kb NB 142-70
Tocris Bioscience, part of Bio-Techne | Catalog # 3962
Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)
Key Product Details
Description
Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)
Product Description
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.Product Specifications
Molecular Weight
251.32
Formula
C11H9NO2S2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
CAS Number
1233533-04-4
PubChem ID
45258277
InChI Key
DHUAGGSHTKPOHU-UHFFFAOYSA-N
SMILES
OC1=CC=C(SC3=C2SCCNC3=O)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.13 | 100 |
Preparing Stock Solutions
for kb NB 142-70
The following data is based on the product molecular weight 251.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.98 mL | 19.89 mL | 39.79 mL |
| 5 mM | 0.80 mL | 3.98 mL | 7.96 mL |
| 10 mM | 0.40 mL | 1.99 mL | 3.98 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bravo-Altamirano Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2011 PMID: 21617763
- Ni PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 2013 PMID: 24039875
- LaValle Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 2010 PMID: 20444281
Product Specific Notices for kb NB 142-70
For research use only
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