GW 843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC₅₀ values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications

Molecular Weight

477.46

Formula

C₂₂H₁₈F₃N₃O₄S

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide

CAS Number

660868-91-7

PubChem ID

9826308

InChI Key

JSKUWFIZUALZLX-UHFFFAOYSA-N

SMILES

O=C(N)C(S3)=C(OCC4=CC=CC=C4C(F)(F)F)C=C3N2C1=CC(OC)=C(OC)C=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.81	75
	Ethanol	2.39	5

Preparing Stock Solutions for GW 843682X

The following data is based on the product molecular weight 477.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.79 mL	13.96 mL	27.93 mL
3.75 mM	0.56 mL	2.79 mL	5.59 mL
7.5 mM	0.28 mL	1.40 mL	2.79 mL
37.5 mM	0.06 mL	0.28 mL	0.56 mL

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Background References

References are publications that support the biological activity of the product.

Lansing In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol.Cancer Ther. 2007 PMID: 17267659

GW 843682X

Tocris Bioscience, part of Bio-Techne | Catalog # 2977

Key Product Details

Description

View all Polo-like Kinase Inhibitors »

Product Description