MRS 2279
Tocris Bioscience, part of Bio-Techne | Catalog # 2158
Selective, high affinity P2Y1 antagonist
Discontinued Product
2158 has been discontinued.
An alternative/replacement product is available:
2159. View all P2Y Receptor Antagonists products.
Key Product Details
Description
Selective, high affinity P2Y1 antagonist
Product Description
MRS 2279 is a selective, high affinity competitive antagonist of the P2Y1 receptor (Ki = 2.5 nM; IC50 = 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y2, P2Y4, P2Y6, P2Y11 and P2Y12) and potently inhibits ADP-induced aggregation of human blood platelets in vitro (pKB = 8.05).Licensing Information
Sold under license from the NIH, US Patent 10/169975Product Specifications
Molecular Weight
503.78
Formula
C13H18ClN5O8P2.2NH3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1R*,2S*)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester diammonium salt
CAS Number
2387505-47-5
PubChem ID
90488744
InChI Key
MLPKPDFUVMQAOX-KOVKCLEESA-N
SMILES
ClC4=NC1=C(C(NC)=N4)N=CN1[C@H]2C[C@H](OP(O)(O)=O)[C@@]3(COP(O)(O)=O)[C@@H]2C3.N.N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.38 | 100 |
Preparing Stock Solutions
for MRS 2279
The following data is based on the product molecular weight 503.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.92 mL | 19.85 mL |
| 5 mM | 0.40 mL | 1.98 mL | 3.97 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Boyer 2-Chloro N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist. Br.J.Pharmacol. 2002 PMID: 11959804
- Kim 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J.Med.Chem 2003 PMID: 14584948
- Nandanan Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands. J.Med.Chem. 2000 PMID: 10715151
Product Specific Notices for MRS 2279
For research use only
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