BGC 20-1531 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5327
High affinity and selective EP4 antagonist
Key Product Details
Description
High affinity and selective EP4 antagonist
Alternative Names
PGN 1531
Product Description
BGC 20-1531 hydrochloride is a high affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.Product Specifications
Molecular Weight
529.00
Formula
C26H24N2O6S.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
CAS Number
1962928-26-2
PubChem ID
121513858
InChI Key
ZSHYZCXOFPPBMH-UHFFFAOYSA-N
SMILES
CC(OC(C(NS(C4=CC=CC=C4C)(=O)=O)=O)=C3)=C3COC(C=C2)=CC=C2C1=NC=C(OC)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.25 | 100 |
Preparing Stock Solutions
for BGC 20-1531 hydrochloride
The following data is based on the product molecular weight 529.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.89 mL | 9.45 mL | 18.90 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.89 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sutton From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg.Med.Chem.Lett. 2014 PMID: 24703233
Product Specific Notices for BGC 20-1531 hydrochloride
For research use only
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