CL 316243 disodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 1499
Highly selective β3 agonist
Key Product Details
Description
Highly selective β3 agonist
Product Description
CL 316243 disodium salt is a potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1 and β2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.Product Specifications
Molecular Weight
465.80
Formula
C20H18ClNNa2O7
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
CAS Number
138908-40-4
PubChem ID
5312115
InChI Key
FUZBPOHHSBDTJQ-CFOQQKEYSA-L
SMILES
[Na+].[Na+].C[C@H](CC1=CC=C2OC(OC2=C1)(C([O-])=O)C([O-])=O)NC[C@H](O)C1=CC=CC(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 46.58 | 100 |
Preparing Stock Solutions
for CL 316243 disodium salt
The following data is based on the product molecular weight 465.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.73 mL | 21.47 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.29 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Woods Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat. J.Urol. 2001 PMID: 11490313
- Yoshida Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β3-adrenoceptor agonist, in yellow KK mice. Life Sci. 1994 PMID: 8309351
- Bloom Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and a J.Med.Chem. 1992 PMID: 1354264
Product Specific Notices for CL 316243 disodium salt
For research use only
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