Adenosine 5'-(α,β-methylene)diphosphate disodium salt

Product Description

Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor, induces inflammation in a rodent model of pleurisy, and reduces memory loss induced by Aβ_1-42 in a mouse model of Alzheimer's disease.

Solubility

Preparing Stock Solutions for Adenosine 5'-(α,β-methylene)diphosphate disodium salt

The following data is based on the product molecular weight 469.19

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.31 mL	106.57 mL	213.13 mL
0.5 mM	4.26 mL	21.31 mL	42.63 mL
1 mM	2.13 mL	10.66 mL	21.31 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Caiazzo The ecto-5'-nucleotidase/CD73 inhibitor, α,β-methylene adenosine 5'-diphosphate, exacerbates carrageenan-induced pleurisy in rat. Front.Pharmacol. 2019 PMID: 31354490
• Chen Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats. ACS Chem.Neurosci. 2019 PMID: 30913879
• Kur Purinergic control of vascular tone in the retina. J.Physiol. 2014 PMID: 24277867
• Ujházy Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer 1996 PMID: 8945621
• Niemelä IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 2008 PMID: 18825744