Cyclopiazonic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 1235
Inhibitor of SERCA ATPase
Key Product Details
Description
Inhibitor of SERCA ATPase
Alternative Names
α-Cyclopiazonic acid
Product Description
Cyclopiazonic acid is a cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.Product Specifications
Molecular Weight
336.39
Formula
C20H20N2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrroloisoindolo[4,5,6-cd]indol-9-one
CAS Number
18172-33-3
PubChem ID
54682463
InChI Key
SZINUGQCTHLQAZ-DQYPLSBCSA-N
SMILES
OC([C@](N4C(C)5C)([H])[C@]1([H])[C@@]5([H])CC3=C2C1=CNC2=CC=C3)=C(C(C)=O)C4=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.64 | 100 |
Preparing Stock Solutions
for Cyclopiazonic acid
The following data is based on the product molecular weight 336.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.86 mL | 29.73 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.30 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Soler Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry 1998 PMID: 9521749
- Takemoto Comparison of contractions produced by CB, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle. Br.J.Pharmacol. 1998 PMID: 9723957
- Plenge-Tellechea On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid. J.Biol.Chem. 1997 PMID: 9006919
Product Specific Notices for Cyclopiazonic acid
For research use only
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