ZYS 1

Name: ZYS 1
Brand: Tocris Bioscience
SKU: 8921

Tocris Bioscience, part of Bio-Techne | Catalog # 8921

COA / SDS

ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor

Key Product Details

Description:	ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor
Chemical Name:	5'-Chloro-5'-deoxy-2-fluoroadenosine
Purity:	≥98% (HPLC)
Molecular Weight:	303.68

View Full Technical Details for ZYS 1

Technical Data
Citations

Biological Activity for ZYS 1

ZYS 1 is an ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor (IC₅₀ = 946 nM). In vitro, ZYS 1 exhibits antiproliferative activity against multiple prostate cancer cell lines. In vivo, ZYS 1 displays antitumor efficacy in prostate cancer cell-derived xenograft mouse model (20 mg and 40 mg per kg (body weight) intraperitoneally, with tumor growth inhibition rates of 66.68% and 81.83%, respectively).

Technical Data for ZYS 1

M. Wt	303.68
Formula	C₁₀H₁₁ClFN₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2734853-80-4
PubChem ID	162354766
InChi Key	HSCKXTNMVCTWGY-UUOKFMHZSA-N
Smiles	NC1=C2C(N([C@@H]3O[C@@H]([C@H]([C@H]3O)O)CCl)C=N2)=NC(F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZYS 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.37	100

Preparing Stock Solutions for ZYS 1

The following data is based on the product molecular weight 303.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.46 mL	32.93 mL
5 mM	0.66 mL	3.29 mL	6.59 mL
10 mM	0.33 mL	1.65 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for ZYS 1

References are publications that support the biological activity of the product.

Wang Targeting ADAR1 with a small molecule for the treatment of prostate cancer. Nat.Cancer 2025 PMID: 39930013