Zonisamide

Name: Zonisamide
Brand: Tocris Bioscience
SKU: 2625
Rating: 5 (1 reviews)

Catalog # 2625 | Tocris Bioscience a Bio-Techne Brand

(1)

COA / SDS

Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)

Key Product Details

Description:	Blocks voltage-sensitive Na⁺ and Ca²⁺ channels (T-type)
Alternative Names:	AD 810, CI 912
Chemical Name:	1,2-Benzisoxazole-3-methanesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	212.22

View Full Technical Details for Zonisamide

Technical Data
Citations / Reviews (1)

Biological Activity for Zonisamide

Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na⁺ and T-type Ca²⁺ channels, stimulates BK_Ca channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Compound Libraries for Zonisamide

Zonisamide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Zonisamide

M. Wt	212.22
Formula	C₈H₈N₂O₃S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	68291-97-4
PubChem ID	5734
InChi Key	UBQNRHZMVUUOMG-UHFFFAOYSA-N
Smiles	NS(=O)(=O)CC1=NOC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zonisamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.12	10
	DMSO	21.22	100

Preparing Stock Solutions for Zonisamide

The following data is based on the product molecular weight 212.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.71 mL	23.56 mL	47.12 mL
5 mM	0.94 mL	4.71 mL	9.42 mL
10 mM	0.47 mL	2.36 mL	4.71 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

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Reconstitution Calculator

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References for Zonisamide

References are publications that support the biological activity of the product.

Huang Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17255467
Gluck Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 2004 PMID: 15168218
Sobieszek Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 2003 PMID: 14704463
Tokumaru In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res. 2000 PMID: 11055748

Citations for Zonisamide

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Customer Reviews for Zonisamide (1)

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Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities

Name: Anonymous

Species: Human

Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.

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