Zolmitriptan

Name: Zolmitriptan
Brand: Tocris Bioscience
SKU: 4657

Tocris Bioscience a Bio-Techne Brand

Catalog # 4657

Citations (1)

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Key Product Details

Description:	Potent 5-HT_1B/1D/1F agonist
Chemical Name:	(4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone
Purity:	≥99% (HPLC)
Molecular Weight:	287.36

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Biological Activity for Zolmitriptan

Zolmitriptan is a potent 5-HT_1B/_1D/_1F agonist (K_i values are 0.63, 5.01 and 63.09 nM for h5-HT_1D, h5-HT_1B and h5-HT_1F receptors respectively). Inhibits trigeminal nerve stimulation-mediated neurogenic plasma protein extravasation in guinea pigs; blocks long excitatory postsynaptic potentials (EPSPs) in a rat model of spinal cord injury.

Compound Libraries for Zolmitriptan

Zolmitriptan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Zolmitriptan

M. Wt	287.36
Formula	C₁₆H₂₁N₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	139264-17-8
PubChem ID	60857
InChi Key	ULSDMUVEXKOYBU-ZDUSSCGKSA-N
Smiles	CN(C)CCC2=CNC1=CC=C(C[C@H](N3)COC3=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zolmitriptan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.74	100
	ethanol	28.74	100

Preparing Stock Solutions for Zolmitriptan

The following data is based on the product molecular weight 287.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.40 mL	34.80 mL
5 mM	0.70 mL	3.48 mL	6.96 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for Zolmitriptan

References are publications that support the biological activity of the product.

Murray Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J.Neurophysiol. 2011 PMID: 21653728
Pauwels How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines. Neuropharmacology 1997 PMID: 9225275
Martin Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). Br.J.Pharmacol. 1997 PMID: 9154322

Citations for Zolmitriptan (1)

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Citations are publications that use Bio-Techne products. Selected citations for Zolmitriptan include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 175
PMID: 32088264

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Product Documents for Zolmitriptan

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.