Zolantidine dimaleate

Name: Zolantidine dimaleate
Brand: Tocris Bioscience
SKU: 1070

Catalog # 1070

Citations (1)

COA / SDS

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Key Product Details

Description:	Potent, centrally active H₂ antagonist
Chemical Name:	N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine dimaleate
Molecular Weight:	613.68

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Biological Activity

Zolantidine dimaleate is a a potent, selective and brain penetrating H₂ receptor antagonist.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt	613.68
Formula	C₂₂H₂₇N₃OS.2C₄H₄O₄
Storage	Desiccate at +4°C
CAS Number	104076-39-3
PubChem ID	11957725
InChi Key	IECBEVAUEBZJCF-SPIKMXEPSA-N
Smiles	OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C(CNC1=NC2=C(S1)C=CC=C2)COC1=CC(CN2CCCCC2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 613.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.15 mL	16.30 mL
5 mM	0.33 mL	1.63 mL	3.26 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References

References are publications that support the biological activity of the product.

Coruzzi Cardiac and gastric effects of histamine H₂ receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity. Br.J.Pharmacol. 1996 PMID: 8842448
Coruzzi Activity of the new histamine H₂-receptor antagonist zolantidine at cardiac and gastric H₂ receptors. Pharmacology 1994 PMID: 7907797
Calcutt Zolantidine (SK&F 95282) is a potent selective brain penetrating histamine H₂-receptor antagonist. Br.J.Pharmacol. 1988 PMID: 2894879

Citations for Zolantidine dimaleate (1)

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Citations are publications that use Bio-Techne products. Selected citations for Zolantidine dimaleate include:

Porter et al. (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 315:711
PMID: 16040814

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