Zatebradine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2202

Blocks hyperpolarization-activated current (If)
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Key Product Details

Description

Blocks hyperpolarization-activated current (If)

Alternative Names

UL-FS 49

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Product Description

Zatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50 of 13.4 μM).

Product Specifications

Molecular Weight

493.04

Formula

C26H36N2O5.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

CAS Number

91940-87-3

PubChem ID

3045335

InChI Key

ZRNKXJHEQKMWCH-UHFFFAOYSA-N

SMILES

Cl.COC1=CC=C(CCN(C)CCCN2CCC3=C(CC2=O)C=C(OC)C(OC)=C3)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 49.3 100

Preparing Stock Solutions for Zatebradine hydrochloride

The following data is based on the product molecular weight 493.04

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.14 mL 20.28 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.20 mL 1.01 mL 2.03 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Product Documents for Zatebradine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Zatebradine hydrochloride

For research use only

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