Z-Guggulsterone

Product Description

Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K_i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K_i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).

Solubility

Preparing Stock Solutions for Z-Guggulsterone

The following data is based on the product molecular weight 312.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.00 mL	80.01 mL	160.03 mL
1 mM	3.20 mL	16.00 mL	32.01 mL
2 mM	1.60 mL	8.00 mL	16.00 mL
10 mM	0.32 mL	1.60 mL	3.20 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Xiao and Singh z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol.Cancer Ther. 2008 PMID: 18202020
• Meyer Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. J.Med.Chem. 2005 PMID: 16250653
• Singh Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate-dependent activation of c-Jun NH₂-terminal kinase. Cancer Res. 2007 PMID: 17671214