Z 944
Tocris Bioscience, part of Bio-Techne | Catalog # 6367
CaV3.x blocker
Product Description
Z 944 is a selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.Product Specifications
Molecular Weight
383.89
Formula
C19H27ClFN3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide
CAS Number
1199236-64-0
PubChem ID
44540045
InChI Key
JOCLITFYIMJMNK-UHFFFAOYSA-N
SMILES
CC(C)(NC(CN1CCC(CC1)CNC(C2=CC(Cl)=CC(F)=C2)=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.39 | 100 | |
| Ethanol | 38.39 | 100 |
Preparing Stock Solutions
for Z 944
The following data is based on the product molecular weight 383.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.60 mL | 13.02 mL | 26.05 mL |
| 5 mM | 0.52 mL | 2.60 mL | 5.21 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.60 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Casillas-Espinosa Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 2015 PMID: 26274319
- Tringham T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 2012 PMID: 22344687
Product Specific Notices for Z 944
For research use only
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