Z 944

Name: Z 944
Brand: Tocris Bioscience
SKU: 6367

Tocris Bioscience, part of Bio-Techne | Catalog # 6367

Citations (10)

COA / SDS

CaV3.x blocker

Key Product Details

Description:	Ca_V3.x blocker
Chemical Name:	4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	383.89

View Full Technical Details for Z 944

Technical Data
Citations

Biological Activity for Z 944

Z 944 is a selective T-type Ca²⁺ channel blocker (IC₅₀ values are 50 to 160 nM for hCa_v3.1, hCa_v3.2 and hCa_v3.3). Exhibits 50 to 600 fold selectivity for Ca_v3.x channels over related ion channels (Ca_v1.2, hERG and Na_v1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.

Compound Libraries for Z 944

Z 944 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Z 944

M. Wt	383.89
Formula	C₁₉H₂₇ClFN₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1199236-64-0
PubChem ID	44540045
InChi Key	JOCLITFYIMJMNK-UHFFFAOYSA-N
Smiles	CC(C)(NC(CN1CCC(CC1)CNC(C2=CC(Cl)=CC(F)=C2)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Z 944

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.39	100
	ethanol	38.39	100

Preparing Stock Solutions for Z 944

The following data is based on the product molecular weight 383.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.02 mL	26.05 mL
5 mM	0.52 mL	2.60 mL	5.21 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for Z 944

References are publications that support the biological activity of the product.

Casillas-Espinosa Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 2015 PMID: 26274319
Tringham T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 2012 PMID: 22344687