YNT 185
Tocris Bioscience, part of Bio-Techne | Catalog # 6739
Potent and selective OX2 agonist
Product Description
YNT 185 is a potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.Product Specifications
Molecular Weight
688.66
Formula
C33H37N5O5S.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride
CAS Number
1804978-82-2
PubChem ID
140307520
InChI Key
AIORBDHFHVKRIY-UHFFFAOYSA-N
SMILES
COC1=C(S(=O)(NC2=CC(NCCNC(C3=C(N(C)C)C=CC=C3)=O)=CC=C2)=O)C=C(C4=CC(C(N(C)C)=O)=CC=C4)C=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 68.87 | 100 | |
| DMSO | 68.87 | 100 |
Preparing Stock Solutions
for YNT 185
The following data is based on the product molecular weight 688.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.45 mL | 7.26 mL | 14.52 mL |
| 5 mM | 0.29 mL | 1.45 mL | 2.90 mL |
| 10 mM | 0.15 mL | 0.73 mL | 1.45 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Irukayama-Tomobe Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 2017 PMID: 28507129
- Nagahara Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 2015 PMID: 26267383
Product Specific Notices for YNT 185
For research use only
Loading...
Loading...