YM 90709

Name: YM 90709
Brand: Tocris Bioscience
SKU: 1675

Tocris Bioscience a Bio-Techne Brand

Catalog # 1675

COA / SDS

Discontinued Product

1675 has been discontinued. View all Cytokine Receptor Antagonists products.

Key Product Details

Description:	Interleukin-5 receptor antagonist
Chemical Name:	5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Purity:	≥99% (HPLC)
Molecular Weight:	359.43

View Full Technical Details for YM 90709

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Biological Activity for YM 90709

YM 90709 is a novel, selective inhibitor of interleukin-5 (IL-5) (IC₅₀ = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo, without affecting peripheral blood or bone marrow leukocytes.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data for YM 90709

M. Wt	359.43
Formula	C₂₂H₂₁N₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	163769-88-8
PubChem ID	1103147
InChi Key	HIXSPVQXXDULHS-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C=C1OC)C1=CC3=NC4=CC=CC=C4N=C3N1C(C)(C)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 90709

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	8.99	25
	DMSO	17.97	50

Preparing Stock Solutions for YM 90709

The following data is based on the product molecular weight 359.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.56 mL	27.82 mL	55.64 mL
2.5 mM	1.11 mL	5.56 mL	11.13 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
25 mM	0.11 mL	0.56 mL	1.11 mL

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References for YM 90709

References are publications that support the biological activity of the product.

Morokata Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol.Lett. 2005 PMID: 15790522
Morokata Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int.Immunopharmacol. 2004 PMID: 15182727
Morokata Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int.Immunopharmacol. 2002 PMID: 12469943

Citations for YM 90709

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