YM 244769

Name: YM 244769
Brand: Tocris Bioscience
SKU: 4544

Tocris Bioscience, part of Bio-Techne | Catalog # 4544

Citations (23)

COA / SDS

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

Key Product Details

Description:	Na⁺/Ca²⁺ exchange inhibitor (reverse mode); neuroprotective
Chemical Name:	N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	516.39

View Full Technical Details for YM 244769

Technical Data
Citations

Biological Activity for YM 244769

YM 244769 is an inhibitor of the reverse mode of Na⁺/Ca²⁺ exchange (NCX). Potently inhibits Na⁺-dependent ⁴⁵Ca²⁺ uptake (IC₅₀ values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na⁺ and Ca²⁺ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Compound Libraries for YM 244769

YM 244769 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YM 244769

M. Wt	516.39
Formula	C₂₆H₂₂FN₃O₃.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1780390-65-9
PubChem ID	90488952
InChi Key	OCKIUNLKEPKCRE-UHFFFAOYSA-N
Smiles	NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 244769

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.64	100

Preparing Stock Solutions for YM 244769

The following data is based on the product molecular weight 516.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.68 mL	19.37 mL
5 mM	0.39 mL	1.94 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for YM 244769

References are publications that support the biological activity of the product.

Iwamoto and Kita YM-244769, a novel Na⁺/Ca²⁺ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol. 2006 PMID: 16973719
Iwamoto Na⁺/Ca²⁺ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets 2007 PMID: 17896959