YKL 5-124
Tocris Bioscience, part of Bio-Techne | Catalog # 7157
Potent and selective CDK7 inhibitor; induces cell cycle arrest
Key Product Details
Description
Potent and selective CDK7 inhibitor; induces cell cycle arrest
Product Description
YKL-5-124 is a potent and selective CDK7/Mat1/CycH and cyclin dependent kinase (CDK7) inhibitor (IC50 values = 9.7 nM and 53.5 nM, respectively). YKL-5-124 shows 100-fold selectivity over CDK9 and CDK2. YKL-5-124 induces cell cycle arrest at the G1/S transition, inhibits E2F-driven gene expression and inhibits CDK1 and CDK3 T-loop phosphorylation.Licensing Information
Sold under license from Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
515.62
Formula
C28H33N7O3
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
CAS Number
1957203-01-8
PubChem ID
121443990
InChI Key
KPABJHHKKJIDGX-JOCHJYFZSA-N
SMILES
CN(C[C@H](C1=CC=CC=C1)NC(N2CC3=C(C2(C)C)NN=C3NC(C4=CC=C(C=C4)NC(C=C)=O)=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.31 | 20 | |
| Ethanol | 10.31 | 20 |
Preparing Stock Solutions
for YKL 5-124
The following data is based on the product molecular weight 515.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.70 mL | 48.49 mL | 96.97 mL |
| 1 mM | 1.94 mL | 9.70 mL | 19.39 mL |
| 2 mM | 0.97 mL | 4.85 mL | 9.70 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Olson Development of a selective CDK7 covalent inhibitor reveals predominant cell-cycle phenotype. Cell Chem.Biol. 2019 PMID: 30905681
Product Specific Notices for YKL 5-124
For research use only
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