XMU MP 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6482
Potent and selective MST1/2 inhibitor; orally bioavailable
Key Product Details
Description
Potent and selective MST1/2 inhibitor; orally bioavailable
Product Description
XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.Licensing Information
Sold under license from Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
416.48
Formula
C17H16N6O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide
CAS Number
2061980-01-4
PubChem ID
121499143
InChI Key
YRDHKIFCGOZTGD-UHFFFAOYSA-N
SMILES
CN1C2=C(C(N(C3=CN=C(N=C13)NC4=CC=C(S(N)(=O)=O)C=C4)C)=O)SC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.65 | 100 |
Preparing Stock Solutions
for XMU MP 1
The following data is based on the product molecular weight 416.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.40 mL | 12.01 mL | 24.01 mL |
| 5 mM | 0.48 mL | 2.40 mL | 4.80 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ray Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 2016 PMID: 27605063
- Crunkhorn Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 2016 PMID: 27681796
- Fan Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 2016 PMID: 27535619
Product Specific Notices for XMU MP 1
For research use only
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