Xamoterol hemifumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 0950
Selective β1 partial agonist
Key Product Details
Description
Selective β1 partial agonist
Alternative Names
ICI 118,587
Product Description
Xamoterol hemifumarate is a β1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors respectively).Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
397.43
Formula
C16H25N3O5.0.5C4H4O4
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate
CAS Number
73210-73-8
PubChem ID
6440459
InChI Key
QEDVGROSOZBGOZ-WXXKFALUSA-N
SMILES
[H]OC(=O)\C=C\C(=O)O[H].OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1.OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50 | ||
| DMSO | 39.74 | 100 |
Preparing Stock Solutions
for Xamoterol hemifumarate
The following data is based on the product molecular weight 397.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 5 mM | 0.50 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Malta The in vitro pharmacology of xamoterol (ICI 118,587). Br.J.Pharmacol. 1985 PMID: 2862938
- Nuttall and Snow The cardiovascular effects of ICI 118,587: a β1-adrenoceptor partial agonist. Br.J.Pharmacol. 1982 PMID: 6128041
- Barlow β-Adrenoceptor stimulant properties of aminoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols. J.Med.Chem. 1981 PMID: 6115058
Product Specific Notices for Xamoterol hemifumarate
For research use only
Loading...
Loading...