XAC

Tocris Bioscience a Bio-Techne Brand

Catalog # 3200

Citations (7)

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Key Product Details

Description:	Adenosine receptor antagonist
Alternative Names:	Xanthine amine congener
Chemical Name:	N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	501.41

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Biological Activity for XAC

XAC is an adenosine receptor antagonist (IC₅₀ values are 1.8 and 114 nM at A₁ and A₂ receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.

Compound Libraries for XAC

XAC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for XAC

M. Wt	501.41
Formula	C₂₁H₂₈N₆O₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1962928-23-9
PubChem ID	121513846
InChi Key	KGNTWECSNGWFKE-UHFFFAOYSA-N
Smiles	O=C1N(CCC)C(C(NC(C3=CC=C(OCC(NCCN)=O)C=C3)=N2)=C2N1CCC)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XAC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.14	100

Preparing Stock Solutions for XAC

The following data is based on the product molecular weight 501.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for XAC

References are publications that support the biological activity of the product.

Wei beta and Grisshammer Purification and characterization of the human adenosine A_2A receptor functionally expressed in Escherichia coli. Eur.J.Biochem. 2002 PMID: 11784301
Sawmiller Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations. Cardiovasc.Res. 1994 PMID: 8025903
Morgan Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC) Life Sci. 1989 PMID: 2779359

Citations for XAC (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for XAC include:

Canas et al. (2019) Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. Eneuro. 5
PMID: 30627646
Wakisaka et al. (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol. 27:1437
PMID: 28502661
Aungraheeta et al. (2016) Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 128:2717
PMID: 27694321
Stoddart et al. (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 12:661
PMID: 26030448
Kaster et al. (2015) Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Hepatology. 112:7833
PMID: 26056314
Kozma et al. (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol. 85:1171
PMID: 23376019
Sousa et al. (2011) Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology. 36:472
PMID: 20927050

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Showing 1 - 7 of 7 citations Showing All

Product Documents for XAC

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

XAC