XAC

Tocris Bioscience, part of Bio-Techne | Catalog # 3200

COA / SDS

Adenosine receptor antagonist

Key Product Details

Description:	Adenosine receptor antagonist
Alternative Names:	Xanthine amine congener
Chemical Name:	N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	501.41

View Full Technical Details for XAC

Technical Data
Citations

Biological Activity for XAC

XAC is an adenosine receptor antagonist (IC₅₀ values are 1.8 and 114 nM at A₁ and A₂ receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.

Compound Libraries for XAC

XAC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for XAC

M. Wt	501.41
Formula	C₂₁H₂₈N₆O₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1962928-23-9
PubChem ID	121513846
InChi Key	KGNTWECSNGWFKE-UHFFFAOYSA-N
Smiles	O=C1N(CCC)C(C(NC(C3=CC=C(OCC(NCCN)=O)C=C3)=N2)=C2N1CCC)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XAC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.14	100

Preparing Stock Solutions for XAC

The following data is based on the product molecular weight 501.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Molarity Calculator

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Reconstitution Calculator

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References for XAC

References are publications that support the biological activity of the product.

Sawmiller Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations. Cardiovasc.Res. 1994 PMID: 8025903
Wei beta and Grisshammer Purification and characterization of the human adenosine A_2A receptor functionally expressed in Escherichia coli. Eur.J.Biochem. 2002 PMID: 11784301
Morgan Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC) Life Sci. 1989 PMID: 2779359

XAC