WY 14643

Name: WY 14643
Brand: Tocris Bioscience
SKU: 1312

Tocris Bioscience, part of Bio-Techne | Catalog # 1312

Citations (39)

COA / SDS

Selective PPARα agonist

Key Product Details

Description:	Selective PPARα agonist
Chemical Name:	[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	323.8

View Full Technical Details for WY 14643

Technical Data
Citations

Biological Activity for WY 14643

WY 14643 is a selective PPARα agonist (EC₅₀ values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.

Compound Libraries for WY 14643

WY 14643 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WY 14643

M. Wt	323.8
Formula	C₁₄H₁₄ClN₃O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	50892-23-4
PubChem ID	5694
InChi Key	SZRPDCCEHVWOJX-UHFFFAOYSA-N
Smiles	CC1=C(C)C(NC2=CC(Cl)=NC(SCC(O)=O)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WY 14643

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.38	100

Preparing Stock Solutions for WY 14643

The following data is based on the product molecular weight 323.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.09 mL	15.44 mL	30.88 mL
5 mM	0.62 mL	3.09 mL	6.18 mL
10 mM	0.31 mL	1.54 mL	3.09 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for WY 14643

References are publications that support the biological activity of the product.

Forman Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A. 1997 PMID: 9113986
Willson The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 2000 PMID: 10691680
Bishop-Bailey Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 2000 PMID: 10696077