WQ 1

Name: WQ 1
Brand: Tocris Bioscience
SKU: 7156
Price: 161 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 7156

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent and selective σ1 receptor antagonist; active in vivo
Alternative Names:	TC WQ 1, TC Sigma1
Chemical Name:	2,3-Dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	337.48

View Full Technical Details for WQ 1

Biological Activity for WQ 1

WQ 1 is a high affinity and selective σ1 receptor antagonist (pK_i values are 10.28-10.85, 5.81-6.53 and 5.80 at σ1, σ2 and DAT). Displays σ1/σ2 selectivity ratio of 29512. Selectively blocks binge eating without a general inhibition of food intake in rats.

Compound Libraries for WQ 1

WQ 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WQ 1

M. Wt	337.48
Formula	C₂₁H₂₃NOS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1204401-49-9
InChi Key	XWMHOCDNGHEUMF-UHFFFAOYSA-N
Smiles	O=C(C1=CC=CC=C1S2)CC2C3CCN(CC4=CC=CC=C4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WQ 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.87	50
	ethanol	3.37	10

Preparing Stock Solutions for WQ 1

The following data is based on the product molecular weight 337.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.93 mL	29.63 mL	59.26 mL
2.5 mM	1.19 mL	5.93 mL	11.85 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
25 mM	0.12 mL	0.59 mL	1.19 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for WQ 1

References are publications that support the biological activity of the product.

Bello Investigation of the role of chirality in the interaction with σ receptors and effect on binge eating episode of a potent σ 1 antagonist analogue of spipethiane. ACS Chem.Neurosci. 2019 PMID: 31298830
Piergentili Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J.Med.Chem. 2010 PMID: 20067271

Citations for WQ 1

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.