WIN 64338 hydrochloride

Name: WIN 64338 hydrochloride
Brand: tocris
SKU: 1057

Catalog # 1057

Citations (1)

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Key Product Details

Description:	Bradykinin B₂ antagonist
Chemical Name:	(S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Molecular Weight:	783.95

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Biological Activity

The first potent, non-peptide, competitive bradykinin B₂ receptor antagonist. In organ bath studies, WIN 64338 inhibits [³H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B₁ preparation).

Technical Data

M. Wt	783.95
Formula	C₄₅H₆₈ClN₄OP.HCl
Storage	Desiccate at +4°C
CAS Number	163727-74-0
PubChem ID	9832172
InChi Key	YYJGBEZPVOUBMJ-KRFCICRISA-N
Smiles	CCCC[P+](CCCC)(CC1=CC=C(C=C1)NC([C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC5=CC=CC=C5C=C4)=O)CCCC.Cl.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	58.8	75

Preparing Stock Solutions

The following data is based on the product molecular weight 783.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	1.70 mL	8.50 mL	17.01 mL
3.75 mM	0.34 mL	1.70 mL	3.40 mL
7.5 mM	0.17 mL	0.85 mL	1.70 mL
37.5 mM	0.03 mL	0.17 mL	0.34 mL

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References

References are publications that support the biological activity of the product.

Hu Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 2004 PMID: 14718600
Marceau Effects of peptide and nonpeptide antagonists of bradykinin B₂ receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 1994 PMID: 8014858
Scherrer Effects of WIN 64338, a nonpeptide bradykinin B₂ receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 1995 PMID: 7582533

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for WIN 64338 hydrochloride include:

Gross et al. (2013) Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Ther. 18:38
PMID: 22407888

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Product Datasheets

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Certificate of Analysis

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WIN 64338 hydrochloride

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Key Product Details

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Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

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