WEB 2086

Tocris Bioscience, part of Bio-Techne | Catalog # 2339

Potent PAF receptor antagonist
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Key Product Details

Description

Potent PAF receptor antagonist

Alternative Names

Apafant

View all Platelet-activating Factor Receptor Antagonists »

Product Description

WEB 2086 is a potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

Product Specifications

Molecular Weight

455.96

Formula

C22H22N5O2SCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine

CAS Number

105219-56-5

PubChem ID

65889

InChI Key

JGPJQFOROWSRRS-UHFFFAOYSA-N

SMILES

CC1=NN=C2CN=C(C3=C(SC(CCC(=O)N4CCOCC4)=C3)N12)C1=CC=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.6 100
Ethanol 45.6 100 with gentle warming

Preparing Stock Solutions for WEB 2086

The following data is based on the product molecular weight 455.96

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.97 mL 21.93 mL
5 mM 0.44 mL 2.19 mL 4.39 mL
10 mM 0.22 mL 1.10 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for WEB 2086

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for WEB 2086

For research use only

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