I have seen the recent news reports that indicate this product can be used to cure baldness. I would like to know how I would place an order or use the product to prevent further hair loss or stimulate hair growth.

Name: WAY 316606 hydrochloride
Brand: Tocris Bioscience
SKU: 4767
Rating: 5 (1 reviews)

I'm sorry for your loss but we will not be able to help you. This product is intended for research use only by trained scientific professionals. It must not under any circumstances be used for human, drug, food, cosmetic, agricultural, domestic or any other unapproved consumer purpose. This product has not undergone the rigorous testing, regulatory inspections and approvals that would be required for a pharmaceutical grade product. We cannot legally sell these products for personal use.

WAY 316606 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4767

(1)

Citations (4)

COA / SDS

Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling

View all beta-Catenin Compounds »

Product Description

WAY 316606 hydrochloride is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.

We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 from Tocris is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.

Product Specifications

Molecular Weight

484.94

Formula

C₁₈H₁₉F₃N₂O₄S₂.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride

CAS Number

1781835-02-6

PubChem ID

25186563

InChI Key

YLOYHLUHXQJNGO-UHFFFAOYSA-N

SMILES

O=S(C1=CC=C(C(F)(F)F)C(S(NC3CCNCC3)(=O)=O)=C1)(C2=CC=CC=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.7	20

Preparing Stock Solutions for WAY 316606 hydrochloride

The following data is based on the product molecular weight 484.94

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.31 mL	51.55 mL	103.11 mL
1 mM	2.06 mL	10.31 mL	20.62 mL
2 mM	1.03 mL	5.16 mL	10.31 mL
10 mM	0.21 mL	1.03 mL	2.06 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Moore Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 2009 PMID: 19072540
Bodine A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 2009 PMID: 19254787
Moore Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 2010 PMID: 19932972