WAY 252623

Name: WAY 252623
Brand: Tocris Bioscience
SKU: 5951

Tocris Bioscience, part of Bio-Techne | Catalog # 5951

COA / SDS

Potent LXR agonist

Key Product Details

Description:	Potent LXR agonist
Chemical Name:	2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Purity:	≥98% (HPLC)
Molecular Weight:	422.78

View Full Technical Details for WAY 252623

Technical Data
Citations

Biological Activity for WAY 252623

WAY 252623 is a potent LXR agonist (IC₅₀ values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for WAY 252623

WAY 252623 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 252623

M. Wt	422.78
Formula	C₂₁H₁₂ClF₅N₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	875787-07-8
PubChem ID	16734800
InChi Key	KYWWJENKIMRJBI-UHFFFAOYSA-N
Smiles	ClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 252623

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.28	100
	ethanol	42.28	100

Preparing Stock Solutions for WAY 252623

The following data is based on the product molecular weight 422.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.83 mL	23.65 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for WAY 252623

References are publications that support the biological activity of the product.

Quinet LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 2009 PMID: 19318684
DiBlasio-Smith Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 2008 PMID: 18925943