WAY 208466 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3904
Selective 5-HT6 agonist
Product Description
WAY 208466 dihydrochloride is a high affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
420.33
Formula
C17H18FN3O2S.2HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
CAS Number
1207064-61-6
PubChem ID
22028182
InChI Key
BAOHMLBVCLITHA-UHFFFAOYSA-N
SMILES
O=S(C2=CN(CCN(C)C)C1=NC=CC=C12)(C3=CC=CC(F)=C3)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.63 | 80 | |
| DMSO | 33.63 | 80 |
Preparing Stock Solutions
for WAY 208466 dihydrochloride
The following data is based on the product molecular weight 420.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.8 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 4 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 8 mM | 0.30 mL | 1.49 mL | 2.97 mL |
| 40 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Carr Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.) 2010 PMID: 20217056
- Schechter Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol 2008 PMID: 17625499
Product Specific Notices for WAY 208466 dihydrochloride
For research use only
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