WAY 100635 maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 4380
Potent 5-HT1A antagonist; also D4 agonist
Key Product Details
Description
Potent 5-HT1A antagonist; also D4 agonist
Product Description
WAY 100635 maleate is a potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.Product Specifications
Molecular Weight
538.64
Formula
C25H34N4O2.C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
CAS Number
1092679-51-0
PubChem ID
11957721
InChI Key
XIGAHNVCEFUYOV-BTJKTKAUSA-N
SMILES
O=C(C4CCCCC4)N(C3=NC=CC=C3)CCN(CC2)CCN2C1=C(OC)C=CC=C1.O=C(\C=C/C(O)=O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 13.47 | 25 |
Preparing Stock Solutions
for WAY 100635 maleate
The following data is based on the product molecular weight 538.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.43 mL | 37.13 mL | 74.26 mL |
| 1.25 mM | 1.49 mL | 7.43 mL | 14.85 mL |
| 2.5 mM | 0.74 mL | 3.71 mL | 7.43 mL |
| 12.5 mM | 0.15 mL | 0.74 mL | 1.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Chemel WAY-100635 is a potent DA D4 receptor agonist. Psychopharmacology (Berl). 2006 PMID: 16915381
- Zhuang Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand. J.Med.Chem. 1994 PMID: 8182697
- Forster A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur.J.Pharmacol. 1995 PMID: 8566121
- Mensonides-Harsema Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635. J.Med.Chem. 2000 PMID: 10669570
Product Specific Notices for WAY 100635 maleate
For research use only
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