Potent and selective S1P1 receptor antagonist
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Key Product Details
Description: | Potent and selective S1P1 receptor antagonist |
Alternative Names: | ML 056 |
Chemical Name: | [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 342.37 |
Citations for W146 (8)
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Citations are publications that use Bio-Techne products. Selected citations for W146 include:
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Chen et al.
(2023)
Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux.
Front Immunol.
14:1090202
PMID: 36798132 -
Richard M et al.
(2022)
Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
Immunity.
55:254-271.e7
PMID: 35139352 -
Lucia et al.
(2021)
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Arterioscler Thromb Vasc Biol.
41:e468-e479
PMID: 34407633 -
Huilan et al.
(2021)
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Proc Natl Acad Sci U S A.
118
PMID: 34873055 -
Hoffmann et al.
(2015)
Fingolimod induces neuroprotective factors in human astrocytes.
J Neuroinflammation.
12:184
PMID: 26419927 -
Schuhmann et al.
(2015)
Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.
Mol Cell Biol.
16:29454
PMID: 26690412 -
Beckham et al.
(2013)
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Oncogenesis.
2:e49
PMID: 23732709 -
Beckham et al.
(2013)
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.
PLoS One.
8:e76593
PMID: 24098536
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