W146

Catalog # 3602 | Tocris Bioscience a Bio-Techne Brand

Potent and selective S1P1 receptor antagonist

Key Product Details

Description:	Potent and selective S1P₁ receptor antagonist
Alternative Names:	ML 056
Chemical Name:	[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	342.37

View Full Technical Details for W146

Technical Data
Citations (8) / Reviews

Biological Activity for W146

W146 is a potent sphingosine-1-phosphate receptor S1P₁ selective antagonist (K_i = 18 nM); displays no effect at S1P₂, S1P₃ or S1P₅. Enhances capillary leakage and restores lymphocyte egress in vivo.

Technical Data for W146

M. Wt	342.37
Formula	C₁₆H₂₇N₂O₄P
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	909725-61-7
PubChem ID	6857802
InChi Key	FWJRVGZWNDOOFH-OAHLLOKOSA-N
Smiles	CCCCCCC1=CC=CC(NC([C@H](N)CCP(O)(O)=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for W146

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	3eq. NaOH	6.85	20

Preparing Stock Solutions for W146

The following data is based on the product molecular weight 342.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.60 mL	73.02 mL	146.04 mL
1 mM	2.92 mL	14.60 mL	29.21 mL
2 mM	1.46 mL	7.30 mL	14.60 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

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Reconstitution Calculator

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References for W146

References are publications that support the biological activity of the product.

Gonzalez-Cabrera Full pharmacological efficacy of a novel S1P₁ agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 2008 PMID: 18708635
Sanna Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P₁ antagonist in vivo. Nat.Chem.Biol. 2006 PMID: 16829954

Citations for W146 (8)

Showing 1 - 8 of 8 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for W146 include:

Chen et al. (2023) Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux. Front Immunol. 14:1090202
PMID: 36798132
Richard M et al. (2022) Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 55:254-271.e7
PMID: 35139352
Lucia et al. (2021) Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein. Arterioscler Thromb Vasc Biol. 41:e468-e479
PMID: 34407633
Huilan et al. (2021) aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 118
PMID: 34873055
Hoffmann et al. (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation. 12:184
PMID: 26419927
Schuhmann et al. (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. Mol Cell Biol. 16:29454
PMID: 26690412
Beckham et al. (2013) Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2:e49
PMID: 23732709
Beckham et al. (2013) Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One. 8:e76593
PMID: 24098536

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