W146
Tocris Bioscience, part of Bio-Techne | Catalog # 3602
Potent and selective S1P1 receptor antagonist
Key Product Details
Description
Potent and selective S1P1 receptor antagonist
Alternative Names
ML 056
Product Description
W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.Product Specifications
Molecular Weight
342.37
Formula
C16H27N2O4P
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
CAS Number
909725-61-7
PubChem ID
6857802
InChI Key
FWJRVGZWNDOOFH-OAHLLOKOSA-N
SMILES
CCCCCCC1=CC=CC(NC([C@H](N)CCP(O)(O)=O)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 3eq. NaOH | 6.85 | 20 |
Preparing Stock Solutions
for W146
The following data is based on the product molecular weight 342.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.60 mL | 73.02 mL | 146.04 mL |
| 1 mM | 2.92 mL | 14.60 mL | 29.21 mL |
| 2 mM | 1.46 mL | 7.30 mL | 14.60 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gonzalez-Cabrera Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 2008 PMID: 18708635
- Sanna Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 2006 PMID: 16829954
Product Specific Notices for W146
For research use only
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