VU 10010
Tocris Bioscience, part of Bio-Techne | Catalog # 3141
Selective positive allosteric modulator of M4 receptors
Key Product Details
Description
Selective positive allosteric modulator of M4 receptors
Product Description
VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.Product Specifications
Molecular Weight
345.85
Formula
C17H16ClN3OS
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
CAS Number
633283-39-3
PubChem ID
714286
InChI Key
FPRULFHDSFKYBV-UHFFFAOYSA-N
SMILES
CC1=C2C(SC(C(NCC3=CC=C(Cl)C=C3)=O)=C2N)=NC(C)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.59 | 100 | |
| Ethanol | 3.46 | 10 |
Preparing Stock Solutions
for VU 10010
The following data is based on the product molecular weight 345.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.89 mL | 14.46 mL | 28.91 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.78 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shirey An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat.Chem.Biol. 2008 PMID: 18059262
Product Specific Notices for VU 10010
For research use only
Loading...
Loading...