VU 0650991
Tocris Bioscience, part of Bio-Techne | Catalog # 6355
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
Key Product Details
Description
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
Product Description
VU 0650991 is a noncompetitive glucagon-like peptide-1 (GLP-1) receptor antagonist (IC50 = 0.65 - 0.69 μM). Displays >40-fold selectivity for GLP-1 receptor over glucagon receptors. Blocks activity of Exendin-4 (Cat. No. 1933) in potentiating insulin secretion from primary mouse pancreatic islets in vitro. Decreases blood insulin and increases blood glucose levels in vivo. Brain penetrant and orally bioavailable.Product Specifications
Molecular Weight
440.73
Formula
C16H11ClF6N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
CAS Number
488097-06-9
PubChem ID
1941609
InChI Key
MFEIZMHODFOWAT-UHFFFAOYSA-N
SMILES
CN1C(N(C2=C(C(C(F)(F)F)(C(F)(F)F)N=C(C3=CC=C(C=C3)Cl)N2)C1=O)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.07 | 100 |
Preparing Stock Solutions
for VU 0650991
The following data is based on the product molecular weight 440.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.34 mL | 22.69 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for VU 0650991
For research use only
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