VU 0463271
Tocris Bioscience, part of Bio-Techne | Catalog # 4719
Potent and selective KCC2 inhibitor
Product Description
VU 0463271 is a potent and selective inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 61 nM); displays >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters.Product Specifications
Molecular Weight
382.50
Formula
C19H18N4OS2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
CAS Number
1391737-01-1
PubChem ID
70690453
InChI Key
DPONSKCACOZTGN-UHFFFAOYSA-N
SMILES
O=C(N(C4CC4)C3=NC(C)=CS3)CSC(C=C2)=NN=C2C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.12 | 50 |
Preparing Stock Solutions
for VU 0463271
The following data is based on the product molecular weight 382.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.23 mL | 26.14 mL | 52.29 mL |
| 2.5 mM | 1.05 mL | 5.23 mL | 10.46 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.23 mL |
| 25 mM | 0.10 mL | 0.52 mL | 1.05 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sivakumaran Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J.Neurosci. 2015 PMID: 26019342
- Delpire Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg.Med.Chem.Lett. 2012 PMID: 22727639
Product Specific Notices for VU 0463271
For research use only
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