VU 0422288
Tocris Bioscience, part of Bio-Techne | Catalog # 5378
Selective positive allosteric modulator of group III mGlu receptors
Key Product Details
Description
Selective positive allosteric modulator of group III mGlu receptors
Alternative Names
ML 396
Product Description
VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.Product Specifications
Molecular Weight
360.19
Formula
C17H11Cl2N3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
CAS Number
1630936-95-6
PubChem ID
73058507
InChI Key
MZRLPXFGQKQHST-UHFFFAOYSA-N
SMILES
ClC1=CC(NC(C3=CC=CC=N3)=O)=CC=C1OC2=CC=C(Cl)C=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.02 | 100 |
Preparing Stock Solutions
for VU 0422288
The following data is based on the product molecular weight 360.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.88 mL | 27.76 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jalan-Sakrikar Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 2014 PMID: 25225882
Product Specific Notices for VU 0422288
For research use only
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